Colorado. My suggestion is, don't try to eat the whole thing. There are obstacles like Gore Canyon that I, at least, never got good enough to attempt. There are dams to be portaged. There are windy, open sections, rather boring, through agricultural land. There are sections where water and resupply will be problematical.
If I wanted to experience what the "upper" Colorado has to offer, I would identify the best sections and knock those off, one by one.
John Wesley Powell did what he could because he had no choice. We have road crossing.
URCHIN Portable Anchor
Touring Kayak Paddles
Kayak Motor Kit
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