You don't mention experience level, canoe or kayak, or level of wilderness desired. Pick up "Quiet Water New York" for a good decription of the entire region plus more. If you don't own a boat and want to portage you will need to find a good outfitter with kevlar canoes (not hard in the Adirondacks). Try going up the week before Labor Day as many people leave because of school. Just make sure you leave before Labor Day weekend if you are looking for solitude. St Regis Canoe Area, Lake Lila, Low's Lake are excellent choices.
Wabakimi Canoe Pack
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