I have a place outside of High Springs and the Suwannee is a good distance from there. The Santa Fe is in High Springs and a nicer paddle in my opinion.
But as far as the Suwannee, I have done the 7 day trip ( 123 mi.) with Paddle Florida in March and the river was coming off flood stage. We put in at the Suwannee River Music Park and it was fun, but the father down the river you got, the tougher the paddle since the river gets wider.