I usually keep mine in an Aquapac like bag and there is no problem with having the screen respond covered.
Garmin also makes a slip case for the Oregon that has a plastic screen cover. It sits away from the face but still allows you to touch the screen. I keep that on all the time as the cover protects the screen, prevents accidental touches and is just as responsive when you actually do want to touch the screen.
Never used it naked on the water but it seems waterproof enough to deal with a wet finger.
Full Size Sail Rig
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